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Defensins ability to influence and direct the adaptive immune system makes defensins promising immune modulators in anti-cancer treatment. Their role in carcinogenesis makes them a fascinating target in the diagnosis and therapy of a growing number of cancers involving head and neck, bone, as well as the gastrointestinal and urinary tracts.
In addition the microbiome modulating effect seems to improve the response rate to anti PD-1 and anti PDL-1 immunotherapy.
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